The Kirby Lab
Neonatal Perinatal Research Institute
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Karen Waldo, M.S.
Research Associate
Medical Illustrator


        


I was trained as a medical illustrator and have been working
with the Kirby group since the mid 1980s. My publications include
articles on cardiac neural crest in the mouse and chick relative
to the development of the aortic arch arteries, coronary arteries,
septation of the outflow tract and the pharyngeal arches. I am
currently studying the secondary heart field in the chick, the
relationship of the cardiac neural crest to the conduction system
in the chick and mouse, and the relationship of coronary artery
development to the formation of pouches in the right ventricular
outflow tract of the Cx43 knockout mouse.




Recent publications

Waldo KL, Zdanowicz M, and Kirby ML 2001
Myocardial changes after neural crest ablation.
(submitted, 2001).

Li WEI, Waldo KL, Linask KK, Kirby ML, and Lo CL 2001
Connexin 43 plays a critical role in mouse coronary artery development by modulating proepicardial cell proliferation
and migration. Development 129, 2031-2042.

Yelbuz TM, Waldo KL, Kumiski DH, Stadt HA, Wolfe RR, Leatherbury LL, Kirby ML 2002
Shortened outflow tract leads to altered cardiac looping after neural crest ablation.
Circulation 106, 504-510.

Waldo KL, Kumiski DH, Wallis KT, Hutson MR, Stadt HA, Platt DH, and Kirby ML 2001
Conotruncal myocardium arises from a secondary heart field.
Development 128, 3179-3188.

Waldo KL, Zdanowicz M, Burch JL, Kumiski DH, Stadt HA, Godt RE, Creazzo TL, and Kirby ML 1999
A novel role for cardiac neural crest in heart development.
J Clin Invest 103:1499-1507.



Favorite data

The moment of truth.
This is a high magnification of the point at which the secondary heart field
(Green, Hnk1-positive) cells begin their maturation into myocardial cells
(Red, MF20-postitive) of the distal outflow tract. Bar=100um.