The Kirby Lab
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Radwan Abu Issa, Ph.D. |
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Recent Publications Abu-Issa R, Kirby ML. Take Heart in the Age of "Omics" Circ. Res. 2004; Aug. 20;95:*** (in press). Abu-Issa R, Waldo K, Kirby ML. Heart fields: one, two or more? Dev Biol. 2004 Aug 15;272(2):281-5. Abu-Issa R, Smyth G, Smoak I, Yamamura K, Meyers EN. Fgf8 is required for pharyngeal arch and cardiovascular development in the mouse. Development. 2002 Oct;129(19):4613-25. Abu-Issa R, Eichele G, Youssoufian H. Expression of the Fanconi anemia group A gene (Fanca) during mouse embryogenesis. Blood. 1999 Jul 15;94(2):818-24. Albrecht U, Abu-Issa R, Ratz B, Hattori M, Aoki J, Arai H, Inoue K, Eichele G. Platelet-activating factor acetylhydrolase expression and activity suggest a link between neuronal migration and platelet-activating factor. Dev Biol. 1996 Dec 15;180(2):579-93. Abu-Issa R, Cavicchi S. Genetic interactions among vestigial, hairy, and Notch suggest a role of vestigial in the differentiation of epidermal and neural cells of the wing and halter of Drosophila melanogaster. J Neurogenet. 1996 Sep;10(4):239-46. |
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Picture legend: Schematic representation, using both chick and mouse data, of heart development from the early gastrula stage to early heart tube stage with emphasis on the embryonic components of the heart (color-coded) derived from the "heart field". (A) Gastrula stage. The heart field is formed by continuous migration of the mesodermal cells through the primitive streak into bilateral positions. (B) Headfold stage. The heart field is still a flat layer of splanchnic mesoderm where cells move medially and the components of the heart change positions relative to each other. (C) Cardiac crescent stage. As the heart fields converge medially, the descending limb fuses first. The cells that will form the anterior limb become cranial as the descending limb folds 180° caudally. (D) Early heart tube stage. The folding continues caudally giving rise to the heart tube with the ascending and descending limbs in a cranial/caudal position. |
